Okay, maybe I'm stupid, but I can't figure this out. Whenever I start the game, everything is off center, so e.g. the SC2 logo appears in the bottom right of the screen instead of the middle. I tried changing the resolution of my monitor, and I still get this problem. I also tried changing the in-game resolution, but I don't think I actually can, because I can't see a "Save Changes" or "Okay" button on the graphics option screen. I assume there's such a button on the right or bottom side, but I can't see it (obviously) because the screen is cut off. So the only way to leave the graphic options menu is to hit escape, which doesn't save any of the changes I just made.

How the balls am I supposed to fix this?

Hello Curiousgrugg

Follow the steps below:
1. Open your "Documents" or "My Documents" folder.
2. Find the Starcraft II folder in this folder and open it
3. Look for a file named Variables.txt, double click on this file to open it.

Locate the lines:

The file should contain many different settings saved in alphabetical order. The lines you will need to find are the following:

height=
refreshrate=
width=

Set the numbers for these lines to match your system display setup, for example:

height=768
refreshrate=60
width=1024

Now save the file and try launching the game again.

Thanks for the update, glad to hear that the issue was resolved.

Let us know if you have any other problems.