This is more of a question for Bashiok but if you can answer, please do! I know I have this problem, i dont know about the rest of you but I have two different computers at two different houses and sometimes I leave my D2 CD at one house and I cant play :( So I was wondering if you need a CD to play D3 or it will be like War3 and WoW and not require a CD. Thanks

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Q u o t e:
http://us.blizzard.com/support/article.xml?locale=en_US&articleId=20758

Patch 1.12

- If all required Diablo 2 '.MPQ' files are installed on the
hard drive, the game will no longer require the CD to play.

For users that originally performed a 'Full Installation'
and wish to run without the CD, all '.MPQ' files should
be copied from the Diablo 2 CDs to the Diablo 2 directory.
Most users will only need to copy D2Music.mpq from the
Diablo 2 Play CD and/or D2xMusic.mpq from the Lord of
Destruction CD. Mac users will need to copy these music
files and rename them to 'Diablo II Music' and
'Diablo II Expansion Music' respectively.

Anyone who did not perform a 'Full Installation' will need
to re-install from CD again to ultimately play without the CD.
In this case, a 'Full Installation' is required, followed by file
copy step noted above.

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You probably either need to do a full install, or more than likely just copy over the music mpq's. Then you should be good to go.